Electrospun aligned PLGA and PLGA/gelatin nanofibers embeddedwith silica nanoparticles for tissue engineering

Electrospun aligned PLGA and PLGA/gelatin nanofibers embeddedwith silica nanoparticles for tissue engineering

اسلاید 1: In the name of GodDr MOEINIElectrospun aligned PLGA and PLGA/gelatin nanofibers embeddedwith silica nanoparticles for tissue engineeringREZA SAEEDI

اسلاید 2: Tissue engineering is an emerging interdisciplinary field whichaims to repair or regenerate injured or missing tissues in the bodyCurrent tissue engineering studies mainly focus on findingappropriate polymeric scaffolds which serve as three-dimensionaltemplates for cell attachment, proliferation, differentiation, andtissue formation.A scaffold with strong cell supporting properties can act as a native extracellular matrix (ECM) for cellsECM is a network of proteins and polysaccharides whichprovides structural support to cells and tissues

اسلاید 3: Accordingly, scaffolds used in tissue engineering should have adequatemechanical and biological properties. Moreover, other featuressuch as high porosity, interconnected pores, biocompatibility,biodegradability, and bioactivity are desiredVarious methods have been used to fabricate polymeric scaffolds for tissue engineering. Among different methods, electrospinning hasattracted a great deal of attention nanofibrous scaffoldsof several biodegradable synthetic polymers such as poly(-caprolactone) (PCL) , poly (lactic acid) (PLA) , poly(glycolicacid) (PGA) , poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) , and poly(lactic-co-glycolic acid) (PLGA) have beenprepared by this method for tissue engineering applications

اسلاید 4: PLGA is oneof the most widely used polymers for the construction of scaffoldsin tissue engineering owing to its prominent characteristics, suchas biocompatibility, biodegradability, valid mechanical properties,and acquisition of FDA approval for human therapyMoreover,PLGA can be readily electrospun into microfibrous or nanofibrousstructuresHowever, PLGA suffers from poor cell-scaffoldattachment and interaction due to its hydrophobic structureand lack of surface cell discrimination point